Just when Ruben Amorim likely believed his luck would never turn, the Red Devils secured the home side's first home defeat in the Premier League from February onward.
The Austrian coach's team dominated early justifiably opened the scoring by way of Jean-Philippe Mateta's retaken penalty. However they failed to make their dominance count and having failed to net versus Palace, the visitors responded with a rapid double from the Dutch forward and Mason Mount.
It was a frustrating encounter finishing following a busy period for the home manager, who observed the Senegalese international limp off with a concerning injury in the first period.
Ruben Amorim may have kept his emotions in check when proceeding toward the dressing room directly following the game's end.
The United manager minimized comparisons between both managers' tactical approach ahead of the match, though recognizing that the opposition "currently execute things better than us|aspects superior to ours|elements more effectively".
The answer to the disappointing loss against 10-man Everton meant modifying both wing-backs, featuring the Ivorian shifting to the right side as Diogo Dalot took over from Dorgu.
Amorim's team probably recognized an opportunity to profit considering they enjoyed extra rest days and almost went ahead inside the opening minute.
An extended delivery generated disorder in the home penalty box but somehow the ex-United shot-stopper produced a point-blank save near the net to stop the Brazilian.
The close shave functioned as a warning for the home team following the midday start that was dictated for broadcast purposes.
Quickly opportunities commenced appearing in quick succession. After missing multiple opportunities in midweek, it looked it might not be the Frenchman's match after he sent shots wide of the target inside the opening 15 minutes.
But in a week when talks over the striker's new deal have stalled, Mateta stepped up who provided the first goal.
A further accurate delivery from the England international enticed the young Frenchman toward the tackle and, having just made excellent defensive stop to prevent the Spaniard, the young defender could only bring down his compatriot in the penalty box.
The goalkeeper returned with head protection to shield his eyes from the glare but he will be disappointed for permitting the visitors to level the score after the restart.
Glasner's team was unprepared from a rapid Fernandes set-piece allowing the forward to bring under control and swivel in the same movement to unleash an attempt that found the top corner.
Having survived a chaotic situation where Zirkzee almost scored another time defensively, their afternoon got even better shortly afterward as the Dutch attacker was fouled near the 18-yard line by Marc Guéhi.
There was a moment's hesitation within the barrier during Fernandes' delivery the dead ball to the midfielder permitting Mount to defeat the goalkeeper with a powerful drive.
Without Sarr's pace to depend on, the home team struggled to create additional opportunities as United were able to see out vital three points which moves United move above Palace to sixth position.
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